Bodor N, Simpkins J W
Science. 1983 Jul 1;221(4605):65-7. doi: 10.1126/science.6857264.
Dopamine was transformed into a redox chemical system for delivery to the brain. The lipoidal form allowed penetration of the blood-brain barrier. Oxidative and hydrolytic processes then transformed the delivery form into a quaternary ammonium precursor of dopamine. The quaternary ammonium precursor was rapidly eliminated from the general circulation, whereas that formed in the brain was locked in, thereby providing a significant and sustained brain-specific dopaminergic activity.
多巴胺被转化为一种用于输送到大脑的氧化还原化学系统。脂质形式使其能够穿透血脑屏障。氧化和水解过程随后将输送形式转化为多巴胺的季铵前体。季铵前体从体循环中迅速清除，而在大脑中形成的则被锁定，从而提供显著且持续的脑特异性多巴胺能活性。
