Punnonen R, Viinamäki O
Surg Gynecol Obstet. 1983 Jun;156(6):781-4.
Plasma vasopressin concentrations were determined in 27 patients undergoing vaginal operations for pelvic relaxation. Thirteen of the 27 patients were operated upon under lumbar epidural analgesia and 14, under general anesthesia. The blood samples for plasma vasopressin determinations were taken before, during and after the operation. The blood pressure and plasma osmolality were measured each time a blood sample was taken. In patients receiving a general anesthetic, the plasma vasopressin concentration was significantly higher 30 minutes after the beginning of the operation and at the end of the operation than immediately before premedication, p less than 0.05. In patients given lumbar analgesia, there were no significant differences among the plasma vasopressin values. Neither in the anesthesia nor in the epidural group was there a significant difference in blood pressure or plasma osmolality. It is concluded that the main cause of vasopressin release after vaginal operations lies in nerve impulses originating at the operative site.
对27例因盆腔松弛接受阴道手术的患者测定了血浆血管加压素浓度。27例患者中，13例在腰段硬膜外镇痛下接受手术，14例在全身麻醉下接受手术。分别于手术前、手术中和手术后采集血样以测定血浆血管加压素。每次采集血样时均测量血压和血浆渗透压。接受全身麻醉的患者，手术开始30分钟后及手术结束时的血浆血管加压素浓度显著高于术前用药前，p<0.05。接受腰段镇痛的患者，血浆血管加压素值之间无显著差异。麻醉组和硬膜外组的血压或血浆渗透压均无显著差异。结论是，阴道手术后血管加压素释放的主要原因在于手术部位产生的神经冲动。
