Burney P G, Britton J R, Chinn S, Tattersfield A E, Papacosta A O, Kelson M C, Anderson F, Corfield D R
Thorax. 1987 Jan;42(1):38-44. doi: 10.1136/thx.42.1.38.
The bronchial response to inhaled histamine has been suggested as an epidemiological tool for assessing the prevalence of asthma, though the exact relationship between reactivity and asthma is unknown. Tests of bronchial reactivity to histamine were carried out in 511 subjects aged 18-64 years, randomly selected from the population in two areas of the South of England, who had returned questionnaires on respiratory symptoms. Bronchial reactivity to less than or equal to 8 mumol histamine was present in 14% and was associated with positive skin test responses to common allergens and with smoking history. Both of these relationships were in turn dependent on age, skin sensitivity being the more important determinant of reactivity in the young and smoking the more important in older subjects. Bronchial reactivity was least prevalent in the 35-44 year age group. No independent effect on reactivity of sex, social class, or area of residence was detected, and no significant effect from recent respiratory tract infections. Interpretation of the bronchial response to histamine in selected groups of subjects must take account of age, atopic state, and smoking history.
吸入组胺后的支气管反应已被提议作为评估哮喘患病率的一种流行病学工具，尽管反应性与哮喘的确切关系尚不清楚。对从英格兰南部两个地区的人群中随机选取的511名年龄在18至64岁之间的受试者进行了组胺支气管反应性测试，这些受试者已返回了关于呼吸道症状的问卷。对小于或等于8微摩尔组胺的支气管反应性在14%的受试者中存在，并且与对常见变应原的皮肤试验阳性反应以及吸烟史相关。这两种关系又都取决于年龄，皮肤敏感性在年轻人中是反应性的更重要决定因素，而吸烟在老年受试者中更重要。支气管反应性在35至44岁年龄组中最为少见。未检测到性别、社会阶层或居住地区对反应性有独立影响，近期呼吸道感染也无显著影响。在特定受试者群体中对组胺支气管反应的解释必须考虑年龄、特应性状态和吸烟史。
