Russell N J, Bagg L R, Dobrzynski J, Hughes D T
Thorax. 1983 Mar;38(3):212-5. doi: 10.1136/thx.38.3.212.
A rebreathing method for measuring carbon monoxide transfer factor (TLCO) and transfer coefficient (KCO) is evaluated. The test was performed on 42 subjects. Seventeen of these had normal lung function while the remainder suffered from various conditions, most having fibrosing alveolitis. No patients with severe airways obstruction were included in the group. The results were compared with single-breath measurements and close correlations were found between single-breath KCO and rebreathing KCO (r = 0.78, p less than 0.001) and between single-breath TLCO and rebreathing TLCO (r = 0.97, p less than 0.001). The reasons for discrepancies between single-breath and rebreathing values are discussed. It is concluded that measurement of rebreathing gas transfer is a useful supplement to routine tests of lung function, particularly in breathless patients with a small vital capacity.
对一种用于测量一氧化碳转移因子（TLCO）和转移系数（KCO）的重复呼吸法进行了评估。该测试在42名受试者身上进行。其中17人肺功能正常，其余受试者患有各种病症，大多数患有纤维化肺泡炎。该组中未纳入严重气道阻塞患者。将结果与单次呼吸测量结果进行比较，发现单次呼吸KCO与重复呼吸KCO之间存在密切相关性（r = 0.78，p < 0.001），单次呼吸TLCO与重复呼吸TLCO之间也存在密切相关性（r = 0.97，p < 0.001）。讨论了单次呼吸值与重复呼吸值之间差异的原因。得出的结论是，重复呼吸气体转移测量是肺功能常规测试的有用补充，特别是对于肺活量小的气喘患者。
