Iogannsen M G, Pliss G B, Vasil'eva I A
Vopr Onkol. 1983;29(4):74-7.
Treatment with 2-naphthylamine was followed by an 1.5-3 fold increase in the frequency of hyperplastic changes in the organ culture cells of rat urinary bladder epithelium, as compared with intact control and cell cultures treated with a non-carcinogenic analog (30.8, 17.6 and 10.7%, respectively). It is suggested that this effect was associated with the initial specific blastogenic effect of 2-naphthylamine metabolites on rat urothelium, the latter being traditionally considered resistant to this agent. Some other factors absent in rats but present in humans and dogs are indispensable for further malignant transformation and tumorigenesis.
与完整对照组和用非致癌类似物处理的细胞培养物相比，用2-萘胺处理后，大鼠膀胱上皮器官培养细胞中增生性变化的频率增加了1.5至3倍（分别为30.8%、17.6%和10.7%）。提示这种效应与2-萘胺代谢产物对大鼠尿路上皮的初始特异性致有丝分裂效应有关，传统上认为后者对该试剂具有抗性。大鼠中不存在但人类和狗中存在的一些其他因素对于进一步的恶性转化和肿瘤发生是不可或缺的。
