Nath N, Pielech M, Dodd R Y
Vox Sang. 1983;44(5):312-8. doi: 10.1111/j.1423-0410.1983.tb04488.x.
A total of 20,643 samples of blood donated to three American Red Cross Blood Service regions were tested for antibodies to hepatitis B core antigen (anti-HBc) in order to evaluate and understand its significance and implications. All 20,643 samples were non-reactive for hepatitis B surface antigen (HBsAg) when screened at the regions. Overall, 2.2% of all samples were found to have anti-HBc, and a total of 16 had anti-HBc in the absence of antibodies to surface antigen (anti-HBs) activity. 1 of the 16 samples with anti-HBc in the absence of anti-HBs was found to have HBsAg when tested by a sensitive procedural modification of the Austria II test. Samples with low levels of anti-HBc activity were significantly more likely to be negative for anti-HBs.
为了评估和理解乙型肝炎核心抗原抗体（抗-HBc）的意义及影响，对捐赠给美国红十字会血液服务三个地区的总共20643份血液样本进行了抗-HBc检测。在这些地区筛查时，所有20643份样本的乙型肝炎表面抗原（HBsAg）均呈阴性反应。总体而言，所有样本中有2.2%被发现含有抗-HBc，共有16份样本在缺乏表面抗原抗体（抗-HBs）活性的情况下含有抗-HBc。在16份缺乏抗-HBs但含有抗-HBc的样本中，有1份样本在采用奥地利II试验的敏感程序改进方法进行检测时被发现含有HBsAg。抗-HBc活性水平较低的样本抗-HBs呈阴性的可能性显著更高。
