茶碱诱发的癫痫发作：临床及病理生理学方面
Theophylline-induced seizures: clinical and pathophysiologic aspects.
作者信息
Nakada T, Kwee I L, Lerner A M, Remler M P
出版信息
West J Med. 1983 Mar;138(3):371-4.
Abstract
The clinical features and management of theophylline-induced seizures are not well appreciated in spite of their unique aspects. These seizures tend to occur in neurologically intact patients and leave no or only minor neurologic sequelae if controlled early. They begin with focal motor seizures with or without secondary generalization and are followed by stupor or coma. They are responsive only to adjustment of theophylline dosage. Should the motor phenomenon persist, it takes the form of epilepsia partialis continua. Extensive workup for a structural brain lesion may be unrewarding. The electroencephalogram typically shows periodic lateralized epileptiform discharges, which may provide a diagnostic clue.
摘要
尽管茶碱诱发的癫痫发作有其独特之处，但对其临床特征及处理方法的认识仍不足。这些癫痫发作往往发生在神经系统正常的患者中，若早期得到控制，不会留下或仅留下轻微的神经后遗症。发作始于局灶性运动性癫痫发作，可伴有或不伴有继发性全身性发作，随后出现昏迷或昏睡。它们仅对茶碱剂量的调整有反应。如果运动现象持续存在，则表现为持续性部分性癫痫。对脑部结构性病变进行广泛检查可能并无结果。脑电图通常显示周期性一侧性癫痫样放电，这可能提供诊断线索。
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