Arushanian E B, Baturin V A, Shishliannikova L V
Biull Eksp Biol Med. 1980 Sep;90(9):296-8.
Bilateral electrolytic lesion of the striatum disturbs the ability of haloperidol (0.1 mg/kg) to normalize the avoidance behaviour of rats given amphetamine (5 mg/kg). Low doses of the neuroleptic (0.03--0.06 mg/kg) potentiate the inhibition of amphetamine-induced stereotypy that occurs after discontinuation of repeated electric stimulation of the cat caudate nucleus. Participation of the striate mechanisms in the realization of specific psychotropic acitivity of neuroleptics is suggested.
纹状体的双侧电解损伤会干扰氟哌啶醇(0.1毫克/千克)使给予苯丙胺(5毫克/千克)的大鼠回避行为恢复正常的能力。低剂量的抗精神病药物(0.03 - 0.06毫克/千克)可增强在对猫尾状核进行重复电刺激停止后出现的对苯丙胺诱导的刻板行为的抑制作用。提示纹状体机制参与了抗精神病药物特定精神活性的实现。