Ekeland A, Myhre L, Underdal T
Acta Orthop Scand. 1983 Jun;54(3):462-9. doi: 10.3109/17453678308996603.
Mechanical properties of healing femoral fractures, intact femora, healing skin wounds and intact skin, have been studied in young male rats during treatment with salmon calcitonin (CT) (3 MCR-U/kg body weight/day). Serum ionized calcium was reduced after each CT injection, and served as a control of the biological activity of the administered hormone. CT did not influence mechanical properties of healing fractures, intact bones or skin wounds. Neither did it change bone growth or body weight of the treated rats. In contrast, injections of the hormone impaired mechanical properties of intact skin Thus, the tensile strength and the ultimate elongation of skin specimens from CT treated rats were reduced by about 20 and 10 per cent respectively compared to controls after 30 days of treatment. The results of the present study do not support the use of salmon CT in the treatment of fractures.
在年轻雄性大鼠接受鲑鱼降钙素（CT）（3 MCR-U/千克体重/天）治疗期间，对愈合中的股骨骨折、完整股骨、愈合中的皮肤伤口和完整皮肤的力学性能进行了研究。每次注射CT后血清离子钙降低，并作为所给予激素生物活性的对照。CT不影响愈合骨折、完整骨骼或皮肤伤口的力学性能。它也不改变治疗大鼠的骨骼生长或体重。相比之下，激素注射损害了完整皮肤的力学性能。因此，治疗30天后，与对照组相比，CT治疗大鼠的皮肤标本的抗张强度和极限伸长率分别降低了约20%和10%。本研究结果不支持使用鲑鱼CT治疗骨折。
