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合成鲑鱼降钙素药理剂量对大鼠伤口愈合的影响。

Effects of pharmacological doses of synthetic salmon calcitonin on wound healing in rats.

作者信息

García García J, Rodriguez Rodriguez J M, Almazan Enriquez A, Gomez Alonso A

出版信息

Int Surg. 1985 Jul-Sep;70(3):243-5.

PMID:3835167
Abstract

The effect of pharmacological doses of synthetic salmon calcitonin (CT) on the healing of experimental wounds in rats is studied. Subcutaneous administration of 20 IU/Kg body weight/day induces a significant increase in collagen content in the scars of treated animals at five, eight, ten and 15 days, as compared with the scars of non-treated animals. The scars of the treated animals also showed a greater tensile strength (TS) than those of the control group, except on day 8.

摘要

研究了药理剂量的合成鲑鱼降钙素(CT)对大鼠实验性伤口愈合的影响。与未治疗动物的疤痕相比,以20 IU/千克体重/天的剂量皮下给药,在第5、8、10和15天时,治疗动物疤痕中的胶原蛋白含量显著增加。除第8天外,治疗动物的疤痕比对照组的疤痕表现出更大的抗张强度(TS)。

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