Blackstone M O, Nemchausky B A
Am J Dig Dis. 1978 Jul;23(7):579-85. doi: 10.1007/BF01072591.
Cholangiographic abnormalities in asymptomatic patients with pericholangitis and long-standing ulcerative colitis, which resemble sclerosing cholangitis, have not been previously reported. Endoscopic retrograde cholangiography (ERC) performed in one such patient suggesting intrahepatic sclerosing cholangitis stimulated the study of seven additional patients with largely asymptomatic pericholangitis. In seven of these eight patients, ERC demonstrated abnormalities which resembled sclerosing cholangitis. These consisted of beading and strictures mainly of the intrahepatic biliary tree (IHB). In two of the eight, the common bile duct was involved. In one, this was associated with histologic progression to cirrhosis and frank cholangitic episodes even though the initial clinical presentation and hepatic histology 2 1/2 years earlier suggested only pericholangitis. We therefore conclude that bile duct abnormalities resembling sclerosing cholangitis may be demonstrated cholangiographically in patients with ulcerative colitis who present with the typical picture of pericholangitis.
无症状的胆管周围炎合并长期溃疡性结肠炎患者中出现类似硬化性胆管炎的胆管造影异常，此前未见报道。对一名此类患者进行的内镜逆行胆管造影（ERC）显示为肝内硬化性胆管炎，这促使对另外7名基本无症状的胆管周围炎患者展开研究。在这8名患者中的7名，ERC显示出类似硬化性胆管炎的异常。这些异常表现为主要累及肝内胆管树（IHB）的串珠样改变和狭窄。8名患者中有2名，胆总管也受累。其中1名患者，尽管最初的临床表现和2年半前的肝脏组织学检查仅提示胆管周围炎，但随后出现了组织学进展至肝硬化以及明显的胆管炎发作。因此，我们得出结论，对于表现出典型胆管周围炎症状的溃疡性结肠炎患者，胆管造影可能显示出类似硬化性胆管炎的胆管异常。
