Rothhammer A, Schmidt E, Bruch H P, Weis K H, Gaertner T
Anaesthesist. 1983 Mar;32(3):111-6.
Intestinal dysfunction is well known after narcotic analgesics and anaesthetics. The site and extent of this action is not really known in man. We investigated the direct effect of morphine, thiopentone and droperidol on human taenia libera in vitro. The spontaneous motility of strips of fresh resected human taenia libera induced by a suitable preload was observed by isometric measurement of developed tension. Cumulative doses of morphine 1 X 10(-8) - 3.89 X 10(-6) g/ml, thiopentone 2.5 X 10(-6) - 9.75 X 10(-5) g/ml or droperidol 2.5 X 10(-8) - 9.72 X 10(-6) g/ml were added to the bath solution. The following parameters were analysed: amplitude, frequency and performance (Montevideo Units MU) of the spontaneous contractions and also the basal tone between contractions. Morphine showed no effects. Thiopentone reduced basal tone to 45.5% of the initial value and frequency to zero. The amplitude of contractions and the MU decreased with thiopentone more than 22.5 X 10(-6) g/ml. All effects are reversible. Droperidol has no significant effects with the exception of a light increase of frequency in high doses. The well known in vivo effect of morphine is therefore not induced by direct action on the smooth muscle of human intestine. Thiopentone in high dose can reduced intestinal motility by direct action on the smooth muscle. Droperidol in the dose used is probably without clinical relevance.
众所周知，使用麻醉性镇痛药和麻醉剂后会出现肠道功能障碍。在人体中，这种作用的部位和程度尚不清楚。我们在体外研究了吗啡、硫喷妥钠和氟哌利多对人游离绦虫的直接作用。通过对等长测量所产生的张力来观察由适当预负荷诱导的新鲜切除的人游离绦虫条带的自发运动。将累积剂量的吗啡1×10（-8）-3.89×10（-6）g/ml、硫喷妥钠2.5×10（-6）-9.75×10（-5）g/ml或氟哌利多2.5×10（-8）-9.72×10（-6）g/ml添加到浴液中。分析了以下参数：自发收缩的幅度、频率和性能（蒙得维的亚单位MU）以及收缩之间的基础张力。吗啡没有显示出作用。硫喷妥钠将基础张力降低至初始值的45.5%，频率降至零。当硫喷妥钠浓度超过22.5×10（-6）g/ml时，收缩幅度和MU降低。所有作用都是可逆的。除高剂量时频率略有增加外，氟哌利多没有显著作用。因此，吗啡在体内的已知作用不是由对人肠道平滑肌的直接作用引起的。高剂量的硫喷妥钠可通过对平滑肌的直接作用降低肠道蠕动。所用剂量的氟哌利多可能与临床无关。
