Listvinova S N, Dmitrieva S V, Zaslavskaia P L, Orlova N V
Antibiotiki. 1979 Dec;24(12):888-93.
Lincomycin added to the cultivation medium induced a number of changes in the organism producing it during its ontogenesis when grown recurrently on liquid media. It was found that lincomycin inhibited the culture growth and decreased the absolute amount of the antibiotic synthesized while the specific activity of the culture increased. A number of cytomorphological rearrangements relevant to the adaptive protective reactions was found. It is suggested that an increase in the resistance of the culture to the antibiotic produced by it at the late developmental stages is the result of the above protective reactions.
当在液体培养基上反复培养时，在其个体发育过程中，添加到培养基中的林可霉素会在产生它的生物体中引起许多变化。研究发现，林可霉素抑制培养物生长，降低合成抗生素的绝对量，同时培养物的比活性增加。还发现了一些与适应性保护反应相关的细胞形态学重排。有人认为，培养物在发育后期对其自身产生的抗生素的抗性增加是上述保护反应的结果。
