Modi N, Keay A J
Arch Dis Child. 1983 Jun;58(6):406-9. doi: 10.1136/adc.58.6.406.
The management of neonatal jaundice can be made much easier using simple methods that increase the radiant energy in the range 420 to 480 nm. Two groups of infants being treated for physiological jaundice during a period of 6 months were compared. The first group received treatment from two unmodified phototherapy units and the second from two units in which the horizontal frames housing the tube lights were lowered, thus providing a higher 'dose' of phototherapy. Measurements of irradiance from the four units were compared. An improvement in treatment was noted in the group receiving the higher dose with a decrease in duration of treatment and a greater rate of fall in the level of serum bilirubin. A dose response relationship was thus confirmed. Comparisons between previous studies are hindered by failure to recognise the varying contribution of background irradiance, the use of radiometers with differing spectral responses, and the use of different units for expressing results. Failure to appreciate the importance of dose must largely be responsible for the present wide variability in the effectiveness of phototherapy.
使用能增加420至480纳米范围内辐射能量的简单方法，可以使新生儿黄疸的治疗变得容易得多。对两组在6个月期间接受生理性黄疸治疗的婴儿进行了比较。第一组接受两个未改装的光疗设备的治疗，第二组接受两个设备的治疗，其中装有灯管的水平框架被降低，从而提供更高的光疗“剂量”。比较了这四个设备的辐照度测量值。接受较高剂量治疗的组治疗效果有所改善，治疗持续时间缩短，血清胆红素水平下降速度更快。因此证实了剂量反应关系。以前的研究之间的比较受到阻碍，原因包括未能认识到背景辐照度的不同贡献、使用具有不同光谱响应的辐射计以及使用不同的单位来表达结果。未能认识到剂量的重要性在很大程度上必定是目前光疗效果差异很大的原因。
