Tan K L
J Pediatr. 1977 Mar;90(3):448-52. doi: 10.1016/s0022-3476(77)80714-2.
The nature of the dose response relationship of phototherapy for neonatal hyperbilirubinemia was studied in 110 infants divided into ten comparable groups; each group was subjected to phototherapy of different intensity. The response to phototherapy increases with increasing dose, but the rate of this response progressively decreases with increasing radiance till a "saturation point" is reached, beyond which no further increase in response occurs to further increase in radiance, i.e., an asymptotic regression was demonstrated. The minimal radiance at which phototherapy begins to be effective for neonatal hyperbilirubinemia was also determined. The rebound after cessation of phototherapy was similar in all groups of infants, despite the shorter duration of exposure required for the groups subjected to intense phototherapy.
对110名婴儿进行了研究，将他们分为10个可比组，以探讨光疗治疗新生儿高胆红素血症的剂量反应关系的性质；每组接受不同强度的光疗。光疗的反应随剂量增加而增加，但随着辐射度增加，这种反应的速率逐渐降低，直到达到一个“饱和点”，超过该点后，辐射度进一步增加，反应不再进一步增加，即呈现渐近回归。还确定了光疗对新生儿高胆红素血症开始有效的最小辐射度。尽管接受强光疗的组所需的暴露时间较短，但所有婴儿组在光疗停止后的反跳情况相似。
