大鼠天然II型胶原诱导性关节炎。III. 对天然II型胶原的细胞免疫反应与关节炎之间的关系。
Native type II collagen-induced arthritis in the rat. III. Relationship between the cellular immune response to native type II collagen and arthritis.
作者信息
Ofosu-Appiah W A, Morgan K, Lennox Holt P J
出版信息
Ann Rheum Dis. 1983 Jun;42(3):331-7. doi: 10.1136/ard.42.3.331.
The relationship between cell mediated immunity to collagen and arthritis was studied with lymphocytes from arthritic and nonarthritic rats after immunisation with native bovine type II collagen. With the in-vivo radiometric ear assay arthritic rats gave a significantly higher response to native type II collagen than did nonarthritic rats. However, there was an overlap of values, and some arthritic rats gave no response to collagen even on the day of onset of arthritis. There was no difference in the response of lymphocytes from arthritic and nonarthritic rats with in-vitro transformation to native type II collagen, responses being found in both groups. All rats which developed arthritis had serum antibodies to native type II collagen, but not all responded to the tests for cell mediated immunity. These findings suggest that antibodies to collagen are more associated with the development of arthritis than is cell mediated immunity to collagen.
在用天然牛II型胶原免疫后，利用关节炎大鼠和非关节炎大鼠的淋巴细胞研究了细胞介导的对胶原免疫与关节炎之间的关系。通过体内放射性耳试验，关节炎大鼠对天然II型胶原的反应明显高于非关节炎大鼠。然而，数值存在重叠，一些关节炎大鼠即使在关节炎发作当天对胶原也无反应。关节炎大鼠和非关节炎大鼠的淋巴细胞对天然II型胶原的体外转化反应没有差异，两组均有反应。所有发生关节炎的大鼠都有针对天然II型胶原的血清抗体，但并非所有大鼠都对细胞介导免疫试验有反应。这些发现表明，与细胞介导的对胶原免疫相比，胶原抗体与关节炎的发生更相关。
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