Averbook B J, Anderson R J
Arch Toxicol. 1983 Mar;52(3):167-72. doi: 10.1007/BF00333896.
Changes in the electrophysiologic activity of the rat sciatic nerve were examined after repeated dosing with either of two organophosphate insecticides, parathion, and trichlorfon. Although the parathion treated animals showed overt signs of systemic toxicity, there were no significant changes in any of the measured parameters of sciatic nerve excitability. Trichlorfon, on the other hand, produced dose-dependent changes in the duration, rise time, relative area, and refractory period of the sciatic nerve compound action potential. The observed changes indicated an increased excitability of the nerve. During the early development of these electrophysiologic changes there were no accompanying histologic changes in the nerve. This suggests that changes in nerve excitability may be a sensitive indicator of neurotoxicity, and that continued trichlorfon exposure may lead to a cumulative alteration in nerve function.
在大鼠反复给予两种有机磷杀虫剂（对硫磷和敌百虫）之一后，检测其坐骨神经电生理活性的变化。虽然用对硫磷处理的动物出现了明显的全身毒性迹象，但坐骨神经兴奋性的任何测量参数均无显著变化。另一方面，敌百虫使坐骨神经复合动作电位的持续时间、上升时间、相对面积和不应期产生剂量依赖性变化。观察到的变化表明神经兴奋性增加。在这些电生理变化的早期发展过程中，神经没有伴随的组织学变化。这表明神经兴奋性的变化可能是神经毒性的一个敏感指标，持续接触敌百虫可能导致神经功能的累积改变。
