体内对照大鼠和胃酸分泌大鼠胃中氨基酸的动静脉差异。
Arteriovenous differences for amino acids across control and acid-secreting rat stomach in vivo.
作者信息
Anderson N G, Hanson P J
出版信息
Biochem J. 1983 Feb 15;210(2):451-5. doi: 10.1042/bj2100451.
Abstract
- A method is described for measuring arteriovenous differences across the rat stomach in vivo. 2. Notable results were the uptake of branched-chain amino acids, the uptake of arginine, which was approximately balanced by an output of ornithine, and the output of alanine. 3. The fractional extraction of glutamine from the blood by the stomach wall of pentagastrin-stimulated rats was 4.7%. 4. The arteriovenous differences for ammonia depended upon the blood ammonia concentration. 5. Arteriovenous differences were not affected by the stimulation of acid secretion with pentagastrin. 6. It is concluded that the high activity of branched-chain-amino-acid aminotransferase (EC 2.6.1.42) in the gastric mucosa is associated with metabolism of these amino acids, but that the stomach wall is a less avid user of glutamine than is the small intestine.
摘要
- 描述了一种在大鼠体内测量胃动静脉差异的方法。2. 显著的结果是支链氨基酸的摄取、精氨酸的摄取（其摄取量大致与鸟氨酸的输出量平衡）以及丙氨酸的输出。3. 五肽胃泌素刺激的大鼠胃壁从血液中提取谷氨酰胺的分数为4.7%。4. 氨的动静脉差异取决于血氨浓度。5. 五肽胃泌素刺激胃酸分泌对动静脉差异没有影响。6. 得出的结论是，胃黏膜中支链氨基酸转氨酶（EC 2.6.1.42）的高活性与这些氨基酸的代谢有关，但胃壁对谷氨酰胺的利用不如小肠活跃。
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