苯丙氨酸负荷对葡萄糖代谢的影响。

The effects of a load of phenĭlalanine on glucose metabolism.

作者信息

Piccardo M G, Rosa M, Russo L

出版信息

Boll Soc Ital Biol Sper. 1983 Jan 31;59(2):167-70.

Abstract

The clinical and experimental hyperphenylalaninemic conditions seem associated with disorders of carbohydrates metabolism. Examples are the increased liver glucose turnover and the glycogen depletion under Phenylalanine load and the hyperexcretion of glucose in the urine of PKU children. We studied the effects of an acute load of Phenylalanine on Glucose-3-H3 kinetics and plasma glucose levels in adult male Wistar rats. The effects of the load were very slow and after 40 minutes we observed an increase in the rate of plasma glucose production (Ra), that in normal animals in an almost exclusive liver function. As result of this glucose production there was a modest increase in plasma glucose levels.

摘要

临床和实验性高苯丙氨酸血症情况似乎与碳水化合物代谢紊乱有关。例如，在苯丙氨酸负荷下肝脏葡萄糖周转率增加、糖原耗竭，以及苯丙酮尿症患儿尿液中葡萄糖排泄过多。我们研究了急性苯丙氨酸负荷对成年雄性Wistar大鼠葡萄糖-3-H3动力学和血糖水平的影响。负荷的影响非常缓慢，40分钟后我们观察到血糖生成率（Ra）增加，而在正常动物中这几乎完全是肝脏的功能。由于这种葡萄糖生成，血糖水平有适度升高。