Saurat J H, Chavez P, Ponvert C, Galloppin L
Br J Dermatol. 1983 Jul;109 Suppl 25:106-10. doi: 10.1111/j.1365-2133.1983.tb11657.x.
Hairless rats fed a hypomagnesaemic diet developed an inflammatory dermatosis characterized by papular erythematous plaques. The dermatosis was long-lasting and could be observed for up to 6 months. It was inhibited by intraperitoneal injection of magnesium or dexamethasone but not by mepyramine, cimetidine, theophylline, aspirin or indomethacin. Analysis of semithin sections only showed oedema in the epidermis and superficial dermis with occasional intra-epidermal splitting. Direct immunofluorescence did not detect immunoreactant deposits within epidermis or dermis. Hypomagnesaemic dermatosis in hairless rats is proposed as a model for the pharmacological study of skin inflammation.
喂食低镁血症饮食的无毛大鼠出现了以丘疹性红斑斑块为特征的炎症性皮肤病。这种皮肤病持续时间长，长达6个月都能观察到。腹腔注射镁或地塞米松可抑制该病，但甲氧苄二胺、西咪替丁、茶碱、阿司匹林或吲哚美辛则无此作用。半薄切片分析仅显示表皮和浅表真皮水肿，偶尔有表皮内分裂。直接免疫荧光未在表皮或真皮内检测到免疫反应物沉积。无毛大鼠的低镁血症性皮肤病被提议作为皮肤炎症药理学研究的模型。
