缺镁无毛大鼠的皮肤病：甾体和非甾体抗炎药的作用

Dermatosis in magnesium-deficient hairless rats: effects of steroidal and non-steroidal anti-inflammatory drugs.

作者信息

Barbier A, Planchenault C, Vernhet C, Brelière J C

出版信息

Agents Actions. 1986 Jan;17(3-4):352-4. doi: 10.1007/BF01982643.

DOI:10.1007/BF01982643

Abstract

Dermatosis in magnesium-deficient hairless rats has been described as a reproducible model of skin inflammation. It was therefore felt of interest to search for the effects of various anti-inflammatory compounds on this model. Results showed that 1) Dexamethasone acetate completely abolished the rash, 2) Indomethacin, a Non-Steroidal Anti-Inflammatory Drug (NSAID), inhibitor of the cyclooxygenase pathway was quite inactive, 3) Benoxaprofen, a NSAID inhibitor of both cyclooxygenase and lipoxygenase pathways only slightly modified the development of the pathology. Activity of steroidal anti-inflammatory drugs on this model may be related to their immunosuppressive effects.

摘要

镁缺乏的无毛大鼠的皮肤病已被描述为一种可重复的皮肤炎症模型。因此，研究各种抗炎化合物对该模型的影响很有意义。结果表明：1）醋酸地塞米松可完全消除皮疹；2）吲哚美辛，一种非甾体抗炎药（NSAID），环氧化酶途径抑制剂，完全无效；3）苯恶洛芬，一种环氧化酶和脂氧合酶途径的NSAID抑制剂，仅略微改变了病理发展。甾体抗炎药对该模型的活性可能与其免疫抑制作用有关。