Haxton M J, Bell J
Br J Obstet Gynaecol. 1983 Jun;90(6):501-6. doi: 10.1111/j.1471-0528.1983.tb08955.x.
Fetuses present in 91 consecutive spontaneous or missed middle-trimester abortions were studied anatomically and tissue karyotyping was attempted. Anatomical abnormalities were found in 32 fetuses, two of these also had chromosomal abnormalities, six of these abortions were associated with other possible aetiological factors. In a further 23 pregnancies there were probably significant aetiological factors associated with the abortion and in 10, where the fetus had arrested growth, there were two with other possible factors. From a prospective analysis of subsequent pregnancies it would appear that if all the factors relating to middle-trimester abortion, including fetal autopsy, are analysed, better patient counselling and realistic prognoses can be given for subsequent pregnancy.
对91例连续发生的中期自然流产或稽留流产中的胎儿进行了解剖学研究，并尝试进行组织核型分析。在32例胎儿中发现了解剖学异常，其中2例同时伴有染色体异常，6例流产与其他可能的病因相关。在另外23例妊娠中，可能存在与流产相关的重要病因，在10例胎儿生长停滞的病例中，有2例存在其他可能因素。通过对后续妊娠的前瞻性分析，似乎如果对与中期流产相关的所有因素，包括胎儿尸检进行分析，就可以为后续妊娠提供更好的患者咨询和现实的预后评估。
