Stewart F, Begg A
Br J Radiol. 1983 Jul;56(667):477-82. doi: 10.1259/0007-1285-56-667-477.
The influence of moderate hyperthermia on the vascular perfusion of four different tumour types and of normal mouse skin was investigated. The 86Rb extraction technique was used to measure changes in perfusion relative to total cardiac output, both during and after a one hour heat treatment at 42.5 degrees C. Perfusion of the SA FA tumour increased slightly during the first 30 minutes of heating but had returned to control values by the end of a 1 hour heating period. After heating, the relative perfusion of all four tumour types fell significantly below control values by 24 hours and remained low for 1-2 days (SA FA tumour) before returning to control values. Relative perfusion of normal skin was progressively increased during heating and remained elevated for 24 hours after the end of treatment before returning to control levels.
研究了中度热疗对四种不同肿瘤类型及正常小鼠皮肤血管灌注的影响。采用⁸⁶Rb提取技术测量在42.5℃进行1小时热处理期间及之后相对于总心输出量的灌注变化。SA FA肿瘤在加热的前30分钟灌注略有增加，但在1小时加热期结束时已恢复到对照值。加热后，所有四种肿瘤类型的相对灌注在24小时时显著低于对照值，并在1 - 2天内（SA FA肿瘤）保持较低水平，然后才恢复到对照值。正常皮肤的相对灌注在加热期间逐渐增加，并在治疗结束后24小时保持升高，然后才恢复到对照水平。
