Roth M S, Donato D M, Lansman H H, Robertson E G, Hsia S L, LeMaire W J
Am J Obstet Gynecol. 1978 Sep 15;132(2):151-6. doi: 10.1016/0002-9378(78)90917-1.
Serum cholesterol binding reserve (SCBR) denotes the capacity of serum to solubilize additional cholesterol. It as been shown previously that a decrease of the SCBR in the presence of elevated cholesterol and/or triglyceride levels is associated with the development of coronary artery disease in man. This is a preliminary report of the effect on serum lipids and SCBR by alteration of the sex steroid environment in women. The hormonal changes associated with pregnancy appear to elevate cholesterol, triglycerides, and SCBR, SCBR being elevated to the greatest extent. No differences were observed in SCBR and serum lipids in a short-term study of premenopausal women when values prior to castration are compared with values after castration during administration of conjugated equine estrogens. In women observed over a period of over 20 weeks, who were using a combination oral contraceptive pill with 1 mg. of norethindrone and 50 or 80 mcg. of mestranol, there was a significant elevation of triglycerides, some decrease of cholesterol, and no change in the SCBR. The possible significance of these findings in relation to the risk of coronary heart disease deserves further investigation.
血清胆固醇结合储备（SCBR）指血清溶解额外胆固醇的能力。先前已有研究表明，在胆固醇和（或）甘油三酯水平升高的情况下，SCBR降低与人冠状动脉疾病的发生有关。这是一份关于女性性类固醇环境改变对血脂和SCBR影响的初步报告。与妊娠相关的激素变化似乎会使胆固醇、甘油三酯和SCBR升高，其中SCBR升高幅度最大。在一项短期研究中，将绝经前女性去势前的SCBR和血脂值与服用结合马雌激素期间去势后的数值进行比较，未观察到差异。在超过20周的观察期内，使用含有1毫克炔诺酮和50或80微克炔雌醇的复方口服避孕药的女性，甘油三酯显著升高，胆固醇有所降低，SCBR无变化。这些发现与冠心病风险相关的潜在意义值得进一步研究。
