与循环性C3肾炎因子导致的持续性补体低下相关的脑膜炎球菌性脑膜炎
Meningococcal meningitis associated with persistent hypocomplementaemia due to circulating C3 nephritic factor.
作者信息
Thompson R A, Yap P L, Brettle R B, Dunmow R E, Chapel H
出版信息
Clin Exp Immunol. 1983 Apr;52(1):153-6.
Abstract
Two teenage patients who presented with meningococcal meningitis were found to have persistently low C3 levels even after recovery. This was accompanied by circulating C3 nephritic factor, which persisted for more than 12 months in each case. Neither patient had evidence of partial lipodystrophy or of glomerulonephritis initially, although one patient subsequently developed mesangioproliferative glomerulonephritis following a second admission with pneumococcal pneumonia. It is possible that the generation of the nephritic factor was initiated during the presenting illness.
摘要
两名患有脑膜炎球菌性脑膜炎的青少年患者即使在康复后，其C3水平仍持续偏低。同时伴有循环C3肾炎因子，且在每个病例中该因子持续存在超过12个月。两名患者最初均无部分脂肪营养不良或肾小球肾炎的证据，尽管其中一名患者在因肺炎球菌肺炎再次入院后，随后发展为系膜增生性肾小球肾炎。肾炎因子的产生有可能是在当前疾病期间开始的。
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