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Identification of the major urinary metabolites of (+)-catechin and 3-O-methyl-(+)-catechin in man.

作者信息

Wermeille M, Turin E, Griffiths L A

出版信息

Eur J Drug Metab Pharmacokinet. 1983;8(1):77-84. doi: 10.1007/BF03189584.

DOI:10.1007/BF03189584
PMID:6861797
Abstract

Following oral administration of (+)-catechin and 3-O-methyl-(+)-catechin to human volunteers the major urinary metabolites were shown to be the glucuronides of 3'-O-methyl-(+)-catechin respectively. Isolations from urine and from synthetic products have been carried out by semi-preparative high performance liquid chromatography; definitive elucidations of structures have been carried out by gas chromatography-mass spectrometry and nuclear magnetic resonance spectroscopy.

摘要

相似文献

1
Identification of the major urinary metabolites of (+)-catechin and 3-O-methyl-(+)-catechin in man.
Eur J Drug Metab Pharmacokinet. 1983;8(1):77-84. doi: 10.1007/BF03189584.
2
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Drug Test Anal. 2017 Aug;9(8):1224-1235. doi: 10.1002/dta.2155. Epub 2017 Feb 10.

本文引用的文献

1
Identification of the major biliary metabolite of (+)-catechin in the rat.大鼠体内（+）-儿茶素主要胆汁代谢物的鉴定
Xenobiotica. 1980 Dec;10(12):905-11. doi: 10.3109/00498258009033824.
2
3'-O-methyl-(+)-catechin glucuronide and 3'-O-methyl-(+)-catechin sulphate: new urinary metabolites of (+)-catechin in the rat and the marmoset.3'-O-甲基-(+)-儿茶素葡萄糖醛酸苷和3'-O-甲基-(+)-儿茶素硫酸盐：大鼠和狨猴体内(+)-儿茶素的新型尿液代谢产物。
Experientia. 1982 May 15;38(5):538-40. doi: 10.1007/BF02327037.
3
The metabolism and excretion of 3-O-methyl-(+)-catechin in the rat, mouse, and marmoset.
3 - O - 甲基 -（+）- 儿茶素在大鼠、小鼠和狨猴体内的代谢与排泄。
Drug Metab Dispos. 1981 Jan-Feb;9(1):54-9.
4
Studies on flavonoid metabolism. Identification of the metabolities of (+)-catechin in rat urine.黄酮类化合物代谢研究。大鼠尿液中（+）-儿茶素代谢产物的鉴定。
Biochem J. 1964 Jul;92(1):173-9. doi: 10.1042/bj0920173.
5
Studies on flavonoid metabolism. Metabolism of (+)-[14C] catechin in the rat and guinea pig.黄酮类化合物代谢研究。大鼠和豚鼠体内(+)-[14C]儿茶素的代谢。
Biochem J. 1969 Dec;115(4):831-6. doi: 10.1042/bj1150831.
6
Studies on flavonoid metabolism. Absorption and metabolism of (+)-catechin in man.黄酮类代谢研究。（+）-儿茶素在人体中的吸收与代谢。
Biochem Pharmacol. 1971 Dec;20(12):3435-45. doi: 10.1016/0006-2952(71)90449-7.
7
Treatment of acute viral hepatitis with (+)-cyanidanol-3.用（+）-儿茶素-3治疗急性病毒性肝炎。
Lancet. 1977 Dec 3;2(8049):1153-5. doi: 10.1016/s0140-6736(77)91540-9.