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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Shaw I C, Griffiths L A

Xenobiotica. 1980 Dec;10(12):905-11. doi: 10.3109/00498258009033824.

Following oral administration of [U-14C]-(+)-catechin to the rat, the major biliary metabolite was shown to be the glucuronide of 3'-O-methyl-(+) catechin by chromatography and mass spectrometry. 2. [methyl-14C]-O-Methyl-(+)-catechin was formed by incubation of (+)-catechin with S-adenosyl-L-[methyl-14C]methionine in vitro in both liver homogenates and in the presence of purified catechol-O-methyl transferase. 3. Alkaline micro-fusion techniques have been used to determine the position of the O-methyl substituent in the B-ring of the isolated O-methyl-(+)-catechin glucuronide.

给大鼠口服[U-14C]-(+)-儿茶素后，通过色谱法和质谱法显示，主要的胆汁代谢产物是3'-O-甲基-(+)-儿茶素的葡糖醛酸苷。2. 在肝匀浆中以及在纯化的儿茶酚-O-甲基转移酶存在的情况下，通过使(+)-儿茶素与S-腺苷-L-[甲基-14C]甲硫氨酸在体外温育，形成了[甲基-14C]-O-甲基-(+)-儿茶素。3. 碱性微熔技术已用于确定分离出的O-甲基-(+)-儿茶素葡糖醛酸苷的B环中O-甲基取代基的位置。

Shaw I C, Griffiths L A

Xenobiotica. 1980 Dec;10(12):905-11. doi: 10.3109/00498258009033824.

Following oral administration of [U-14C]-(+)-catechin to the rat, the major biliary metabolite was shown to be the glucuronide of 3'-O-methyl-(+) catechin by chromatography and mass spectrometry. 2. [methyl-14C]-O-Methyl-(+)-catechin was formed by incubation of (+)-catechin with S-adenosyl-L-[methyl-14C]methionine in vitro in both liver homogenates and in the presence of purified catechol-O-methyl transferase. 3. Alkaline micro-fusion techniques have been used to determine the position of the O-methyl substituent in the B-ring of the isolated O-methyl-(+)-catechin glucuronide.

给大鼠口服[U-14C]-(+)-儿茶素后，通过色谱法和质谱法显示，主要的胆汁代谢产物是3'-O-甲基-(+)-儿茶素的葡糖醛酸苷。2. 在肝匀浆中以及在纯化的儿茶酚-O-甲基转移酶存在的情况下，通过使(+)-儿茶素与S-腺苷-L-[甲基-14C]甲硫氨酸在体外温育，形成了[甲基-14C]-O-甲基-(+)-儿茶素。3. 碱性微熔技术已用于确定分离出的O-甲基-(+)-儿茶素葡糖醛酸苷的B环中O-甲基取代基的位置。