The effect of piroxicam on neutrophil and monocyte-macrophage function.

The effect of piroxicam on neutrophil and monocyte chemotaxis was evaluated in vitro and in vivo. Piroxicam demonstrated a marked inhibitory activity on neutrophil chemotaxis and to a lesser extent on monocyte chemotaxis. The data here presented supports the notion that piroxicam interfere with the inflammatory process by affecting primarily neutrophil and to a lesser degree monocyte function.