Brown P J, Dusci L J, Shenfield G M
Eur J Clin Pharmacol. 1983;24(4):525-7. doi: 10.1007/BF00609897.
Oral theophylline was given to 6 adults with airways obstruction. The initial dose was 125 mg daily and this was increased by 125 mg each week. The final total daily dose reached was determined by side effects and ranged from 500 mg to 1125 mg. At the end of each week and before the next dosage increment steady state, trough plasma theophylline concentrations were measured. For each individual and for the group as a whole there was a highly significant linear correlation between theophylline dose and trough plasma concentration. This indicates that for oral theophylline, in adults, dose-dependent kinetics do not play a significant role and dose may be adjusted without fear of a disproportionate rise in plasma concentration.
给6名患有气道阻塞的成年人服用口服氨茶碱。初始剂量为每日125毫克，每周增加125毫克。最终达到的每日总剂量由副作用决定，范围为500毫克至1125毫克。在每周结束时以及下次剂量增加前的稳态时，测量血浆氨茶碱谷浓度。对于每个个体以及整个群体而言，氨茶碱剂量与血浆谷浓度之间存在高度显著的线性相关性。这表明对于成年人口服氨茶碱，剂量依赖性动力学不起显著作用，剂量可以调整而不用担心血浆浓度不成比例地升高。
