Blöndal T, Arnorsson T, Bengtsson A, Wilander E
Eur J Respir Dis. 1983 May;64(4):298-305.
Fluorescence cytophotometric DNA measurements on 15 carcinoid tumours generally yielded histograms with a prominent G1-phase peak and only low frequencies of S- and G2-phase nuclei. In 13 tumours the modal DNA value was near diploid (1.75-2.25). Three of these 15 tumours showed a much greater number of S- and G2-phase values than the others and in two of them there were also G1-phase peaks below the near-diploid range. Among 22 samples of small cell carcinoma of the lung (SCCL), the modal DNA value was hypodiploid in two, near diploid in seven and hyperdiploid in 13. The proportion of S-phase cells was higher in the SCCL samples than in the carcinoid tumours. It is suggested that the nuclear DNA distribution profile may facilitate morphological discrimination of a classical pulmonary carcinoid from small cell carcinoma. In a borderline case, the finding of a hyperdiploid DNA stem line and high proliferative activity will favour the diagnosis of SCCL.
对15例类癌肿瘤进行荧光细胞光度法DNA测量，所得直方图通常显示G1期峰明显，而S期和G2期细胞核频率较低。在13例肿瘤中，DNA众数接近二倍体（1.75 - 2.25）。这15例肿瘤中有3例显示S期和G2期值的数量比其他肿瘤多得多，其中2例在接近二倍体范围以下也有G1期峰。在22例肺小细胞癌（SCCL）样本中，DNA众数在2例中为亚二倍体，7例中接近二倍体，13例中为超二倍体。SCCL样本中S期细胞的比例高于类癌肿瘤。有人认为，核DNA分布图谱可能有助于从形态学上区分典型的肺类癌和小细胞癌。在临界病例中，发现超二倍体DNA干系和高增殖活性将有利于SCCL的诊断。
