Jones D J, Hasleton P S, Moore M
Paterson Institute for Cancer Research, Christie Hospital, Manchester.
Thorax. 1988 Mar;43(3):195-9. doi: 10.1136/thx.43.3.195.
Fifty three bronchopulmonary carcinoid tumours were studied to assess the significance of DNA ploidy, determined by flow cytometry of paraffin embedded tissue. Twenty eight were typical carcinoid tumours and 25 well differentiated neuroendocrine carcinomas. Twenty seven were DNA diploid and 26 DNA aneuploid. DNA aneuploidy was significantly associated with histological features of increased malignant potential. Survival data were available for 43 patients. Of the 19 with DNA diploid tumours, 16 survived five years, compared with 14 of 24 with DNA aneuploid tumours--the difference being at the borderline of statistical significance. In a Cox multivariate regression analysis with other histological variables, DNA ploidy did not confer independent prognostic information. It is concluded that, although DNA aneuploidy as determined by flow cytometry is an indicator of increased malignant potential in bronchopulmonary carcinoid tumours, it does not provide clinically useful information additional to the results of routine histological examination.
对53例支气管肺类癌肿瘤进行了研究，以评估通过石蜡包埋组织的流式细胞术测定的DNA倍性的意义。其中28例为典型类癌肿瘤，25例为高分化神经内分泌癌。27例为DNA二倍体，26例为DNA非整倍体。DNA非整倍体与恶性潜能增加的组织学特征显著相关。有43例患者的生存数据。在19例DNA二倍体肿瘤患者中，16例存活了5年，而在24例DNA非整倍体肿瘤患者中，有14例存活5年——差异处于统计学意义的临界值。在一项包含其他组织学变量的Cox多变量回归分析中，DNA倍性并未提供独立的预后信息。得出的结论是，尽管通过流式细胞术测定的DNA非整倍体是支气管肺类癌肿瘤恶性潜能增加的一个指标，但它并不能提供常规组织学检查结果之外的临床有用信息。
