特异性和非特异性免疫复合物对体外完整肝细胞损伤的影响。
Effect of specific and nonspecific immune complexes on injury of intact hepatocytes in vitro.
作者信息
Kawanishi H
出版信息
Experientia. 1983 Jul 15;39(7):769-71. doi: 10.1007/BF01990318.
PMID:6861968
Abstract
Immune complex (IC)-mediated cytotoxicity of hepatocytes was investigated in vitro, using antibodies against specific and nonspecific target cell surface membranes. The results indicated that neither specific, nor nonspecific IC evoked significant lysis of intact hepatocytes. Thus, the IC are unlikely to play an important role in the immune-associated injury of normal hepatocytes in acute and chronic liver diseases.
摘要
利用针对特异性和非特异性靶细胞表面膜的抗体，在体外研究了免疫复合物（IC）介导的肝细胞细胞毒性。结果表明，特异性和非特异性IC均未引起完整肝细胞的显著裂解。因此，IC不太可能在急慢性肝病中正常肝细胞的免疫相关损伤中起重要作用。
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