[非甾体抗炎药。2-(-4-联苯基)-3-氧代丁酸的立体异构体]
[Non-steroid anti-inflammatory agents. Stereoisomers of 2-(-4-biphenylyl)-3-oxybutyric acid].
作者信息
Guarnieri A, Scapini G, Burnelli S, Andreani A
出版信息
Farmaco Sci. 1977 May;32(5):324-32.
PMID:862887
Abstract
The synthesis, diastereoisomeric separation, attribution to erythro and threo series, and resolution of the enantiomers of 2-(4-biphenylyl)-3-oxybutyric acid are described. The four isomers were tested for anti-inflammatory activity: the preliminary results are interesting, particular those for the (--) erythro enantiomer.
摘要
本文描述了2-(4-联苯基)-3-氧代丁酸的合成、非对映异构体分离、赤型和苏型系列归属以及对映体拆分。对这四种异构体进行了抗炎活性测试：初步结果很有意思，尤其是（--）赤型对映体的结果。
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