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利用针对人乙酰胆碱受体的单克隆抗体对人肌肉中乙酰胆碱受体主要免疫原性区域的展示。

Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptor.

作者信息

Tzartos S, Langeberg L, Hochschwender S, Lindstrom J

出版信息

FEBS Lett. 1983 Jul 11;158(1):116-8. doi: 10.1016/0014-5793(83)80688-7.

DOI:10.1016/0014-5793(83)80688-7
PMID:6862030
Abstract

Eleven cloned hybridomas which secrete antibodies to acetylcholine receptors from human muscle have been prepared. All of these monoclonal antibodies to have the same basic specificity as shown by competition for binding to the main immunogenic region on the receptor, but these antibodies differ in fine specificity as shown by reaction with denatured receptor subunits and interspecies cross-reaction.

摘要

已经制备了11种克隆杂交瘤，它们分泌针对人肌肉中乙酰胆碱受体的抗体。所有这些抗乙酰胆碱受体的单克隆抗体在与受体主要免疫原性区域结合的竞争中显示出相同的基本特异性，但这些抗体在与变性受体亚基反应和种间交叉反应中显示出精细特异性的差异。

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