Beller U, Bigelow B, Beckman E M, Brown B, Demopoulos R I
Gynecol Oncol. 1983 Jun;15(3):422-7. doi: 10.1016/0090-8258(83)90061-6.
In the 10-year interval from 1972 through 1981, 247 patients were treated for epithelial ovarian carcinoma at New York University Medical Center. Of this group, 31 patients (12.6%) were below age 40, and this group had distinctive features favoring longer survival. Of these patients 12 (38.7%) had borderline tumors, compared to 9 of 216 patients (4.2%) over 40 years of age (P less than 0.001). Stage I disease and well differentiated lesions were also common in the younger group. Early symptomatology and frequent gynecologic examinations during the childbearing years may also contribute to early detection of these tumors. The median survival in this group (7 years) was better than that reported for all ages. After careful evaluation, conservative surgical management can be considered for patients with Stage Ia disease which is either borderline or grade 1 carcinoma.
在1972年至1981年的10年期间，纽约大学医学中心有247例上皮性卵巢癌患者接受了治疗。在这组患者中，31例（12.6%）年龄在40岁以下，该组具有有利于延长生存期的独特特征。在这些患者中，12例（38.7%）患有交界性肿瘤，而40岁以上的216例患者中有9例（4.2%）患有交界性肿瘤（P<0.001）。I期疾病和高分化病变在较年轻组中也很常见。生育期的早期症状和频繁的妇科检查也可能有助于这些肿瘤的早期发现。该组的中位生存期（7年）优于所有年龄段报告的生存期。经过仔细评估，对于Ia期交界性或1级癌患者可考虑采取保守手术治疗。
