Baron M
Hum Hered. 1983;33(2):112-8. doi: 10.1159/000153360.
A single major locus model of inheritance that incorporates polarity (bipolar-unipolar distinction) and sex effect was applied to family study data on bipolar and unipolar affective disorders. In the model tested, clinical polarity and sex-related thresholds determined a differential liability to major affective illness, whereby unipolar females and bipolar males represented two extremes on a genetic-environmental continuum. Bipolar males were more deviant, and unipolar females were less deviant genetically than bipolar females and unipolar males. The major locus hypothesis did not provide an acceptable fit to the data. The implications of these findings for genetic and biological research in affective disorders are discussed.
一个包含极性（双相-单相区别）和性别效应的单一位点遗传模型被应用于双相情感障碍和单相情感障碍的家系研究数据。在测试的模型中，临床极性和与性别相关的阈值决定了患主要情感障碍的不同易感性，据此，单相女性和双相男性代表了遗传-环境连续体上的两个极端。双相男性偏离程度更大，单相女性在遗传上比双相女性和单相男性偏离程度更小。主要位点假说未能很好地拟合数据。文中讨论了这些发现对情感障碍遗传和生物学研究的意义。
