Jakimow-Venulet B
Br J Psychiatry. 1981 Nov;139:450-6. doi: 10.1192/bjp.139.5.450.
The purpose of the study was verification of a genetic distinction between bipolar and unipolar affective illness and investigation of hypotheses concerning the mode of genetic transmission of both illnesses. The investigation demonstrated a difference between a group of 150 probands with bipolar affective illness and 50 probands with unipolar affective illness. A genetic-correlation analysis of both diseases showed that they are determined by different, partly correlated liabilities. Evaluation of the mode of inheritance suggests an multifactorial mode of inheritance of both affective illnesses: although genetic factors are of basic importance, continuously acting environmental factors also have a significant influence on the manifestation of the illness. The results suggest possible heterogeneity of both illnesses from the genetic standpoint.
该研究的目的是验证双相情感障碍和单相情感障碍之间的遗传差异，并调查有关这两种疾病遗传传递模式的假设。调查显示，一组150例双相情感障碍先证者和50例单相情感障碍先证者之间存在差异。对这两种疾病的遗传相关性分析表明，它们由不同的、部分相关的易感性决定。对遗传模式的评估表明，这两种情感障碍均为多因素遗传模式：尽管遗传因素至关重要，但持续起作用的环境因素对疾病的表现也有显著影响。结果表明，从遗传学角度来看，这两种疾病可能存在异质性。
