单相情感障碍中性别效应的遗传模型。

Genetic models of sex effect in unipolar affective illness.

作者信息

Baron M

出版信息

Acta Psychiatr Scand. 1981 Jul;64(1):85-91. doi: 10.1111/j.1600-0447.1981.tb00762.x.

DOI:10.1111/j.1600-0447.1981.tb00762.x

Abstract

Family study data on unipolar affective illness are analyzed by multiple threshold models of inheritance that incorporate sex effect. In these models males and females share a common genetic-environmental liability, but the less prevalent sex, i.e., males, has a higher genetic threshold for the disorder. Neither single major locus (SML) nor multifactorial-polygenic (MFP) transmission can account for the sex differences in the morbid risk for unipolar disorder. The implications for genetic research in affective disorders are discussed.

摘要

对单相情感障碍的家系研究数据，采用纳入性别效应的多阈值遗传模型进行分析。在这些模型中，男性和女性具有共同的遗传 - 环境易感性，但发病率较低的性别，即男性，患该疾病的遗传阈值更高。单一位点（SML）遗传和多因素 - 多基因（MFP）遗传均无法解释单相情感障碍发病风险中的性别差异。文中讨论了这些发现对情感障碍遗传研究的意义。