Kosugi T, Takagi I, Kinjo K, Aratake Y, Ohtaki S, Mihara H
Int J Tissue React. 1983;5(1):47-53.
In order to clarify the pathophysiological significance of the fibrinogen (FgDP)-protamine complex, the interaction between fibrinogen and protamine sulphate was studied in vitro and in vivo. Using the electrophoretic technique, an attempt was made to determine whether the complex could be detected in vitro and in the circulating blood. From the present studies, it has been clarified in in vitro experiments that the slower mobility of two peaks on immunoelectrophoresis represented a complex of protamine sulphate and fibrinogen (FgDP). Furthermore, the peak of slower mobility on crossed immunoelectrophoresis appeared in the circulating blood of a rabbit receiving administration of excess protamine sulphate. That is, in vivo experiments showed that a complex of protamine sulphate and fibrinogen (FgDP) could be detected in the circulating blood.
为阐明纤维蛋白原（FgDP）-鱼精蛋白复合物的病理生理意义，对纤维蛋白原与硫酸鱼精蛋白之间的相互作用进行了体内外研究。采用电泳技术，试图确定该复合物能否在体外及循环血液中被检测到。从目前的研究来看，体外实验已明确，免疫电泳上两个峰迁移速度较慢代表硫酸鱼精蛋白与纤维蛋白原（FgDP）的复合物。此外，在接受过量硫酸鱼精蛋白给药的兔子的循环血液中，交叉免疫电泳上迁移速度较慢的峰出现了。也就是说，体内实验表明，在循环血液中可检测到硫酸鱼精蛋白与纤维蛋白原（FgDP）的复合物。
