Pool R R, Morgan J P, Parks N J, Farnham J E, Littman M S
Health Phys. 1983;44 Suppl 1:155-77. doi: 10.1097/00004032-198306001-00013.
Morphologic changes resulting from the effects of chronic radionuclide toxicity (226Ra) in the skeletons of workers in the radioluminescent dial painting industry with preterminal body burdens ranging from about 1.5 to 0.042 muCi were compared with the pathologic alterations in the skeletons of a group of 38 beagle dogs injected with 1.12 muCi/kg. Similarities observed in the skeletal responses of the two species were the presence of (1) dead bone tissue with delayed resolution, (2) a chronic disturbance in the remodeling mechanism of bone tissue, and (3) radiation-induced bone sarcomas. A detailed analysis of sequential changes in radiographic lesions arising in the beagle skeletons, complemented by histopathologic evaluation at the time of limb amputation or at necropsy, has enabled us to examined the disturbance in the bone remodeling process. The perturbation of critical importance in the generation of primary bone tumors appears to lie in the bone tissue formation and deposition phase of the bone remodeling process and gives rise to a spectrum of histologic patterns which we have termed "radiation osteodystrophy." While some of the newly generated patterns demonstrate indolent behavior with fibrous tissue replacement and bone marrow refill, other sites of bone resorption are replaced by a unique fibro-osseous tissue response resembling fibrous dysplasia or osteoblastoma. Some of these proliferative lesions may undergo progressive malignant degeneration. While the more indolent part of the spectrum was also seen in human skeletal tissues, only premalignant and early sarcomatous stages were seen in canine tissues.
将发光表盘涂漆行业中终末期身体负荷约为1.5至0.042微居里的工人骨骼中慢性放射性核素毒性（226镭）影响所导致的形态学变化，与一组注射了1.12微居里/千克的38只比格犬骨骼中的病理改变进行了比较。在两个物种的骨骼反应中观察到的相似之处包括：（1）存在延迟溶解的死骨组织；（2）骨组织重塑机制的慢性紊乱；（3）辐射诱导的骨肉瘤。对比格犬骨骼中出现的放射影像学病变的连续变化进行详细分析，并辅以肢体截肢时或尸检时的组织病理学评估，使我们能够研究骨重塑过程中的紊乱情况。在原发性骨肿瘤发生过程中至关重要的扰动似乎在于骨重塑过程中的骨组织形成和沉积阶段，并产生了一系列我们称之为“放射性骨营养不良”的组织学模式。虽然一些新产生的模式表现为纤维组织替代和骨髓再填充的惰性行为，但其他骨吸收部位则被一种类似于纤维发育不良或成骨细胞瘤的独特纤维骨组织反应所取代。这些增殖性病变中的一些可能会发生进行性恶性退变。虽然在人类骨骼组织中也观察到了该谱系中较为惰性的部分，但在犬类组织中仅观察到了癌前和早期肉瘤阶段。
