Simmons D J, Holtzman R B
Health Phys. 1983;44 Suppl 1:179-86. doi: 10.1097/00004032-198306001-00014.
Haversian canal plugging is a common lesion in bone from human radium cases, signaling vascular damage. Its incidence is correlated with the whole body radium dose. However, since the vascular supply to bone forms an extensive anastomotic plexus facilitating propagation of vascular damage from a primary site of high radium content, we do not know if the degree of plugging is related to the local bone dose. In this report, we compare the incidence of plugging of osteons in different regions (16 sections) of humeri of three radium cases with terminal 226Ra body contents of 0.203, 1.03 and 15.4 muCi to the local dose of radium in adjacent bone sections. While the first and third subjects had received 226Ra only, the second had had a large intake of 228Ra as well. The background incidence of plugging in 35 "normal" humeri from dissecting room populations (45-90 yr) ranged from 0 to 1%, with an average of 0.3%. The least squares linear regression equation for the relation between the percent of canals plugged (PCP) and dose, PCP = (0.00214 +/- 0.00014) rad + (3.26 +/- 3.6), predicts for our three radium cases a development of about 0.002% plugs/rad. The correlation coefficient was very high (r = 0.97, n = 16, P less than 0.01). When normalized to radiation dose from the two decay series, 226Ra and 228Ra appear to be equally effective in producing plugged canals.
哈弗斯管堵塞是人类镭中毒病例骨骼中的常见病变，表明血管受损。其发生率与全身镭剂量相关。然而，由于骨骼的血管供应形成了广泛的吻合丛，促进了血管损伤从高镭含量的原发部位传播，我们不知道堵塞程度是否与局部骨剂量有关。在本报告中，我们比较了三名镭中毒病例肱骨不同区域（16个切片）中骨单位堵塞的发生率，这三名病例的体内226镭终含量分别为0.203、1.03和15.4微居里，并将其与相邻骨切片中的局部镭剂量进行比较。虽然第一个和第三个受试者仅接受了226镭，但第二个受试者还大量摄入了228镭。来自解剖室人群（45 - 90岁）的35根“正常”肱骨的堵塞背景发生率在0%至1%之间，平均为0.3%。堵塞管百分比（PCP）与剂量之间关系的最小二乘线性回归方程为PCP =（0.00214 ± 0.00014）拉德 +（3.26 ± 3.6），该方程预测我们的三名镭中毒病例每拉德约有0.002%的堵塞发生率。相关系数非常高（r = 0.97，n = 16，P < 0.01）。当根据两个衰变系列的辐射剂量进行归一化时，226镭和228镭在产生堵塞管方面似乎同样有效。
