Schmitt E, Rückbeil C, Wick R R
Health Phys. 1983;44 Suppl 1:197-202. doi: 10.1097/00004032-198306001-00016.
Between 1952 and 1980 about 250 patients with ankylosing spondylitis were treated with 224Ra at the Orthopaedic University Hospital of Frankfurt/M. In 1970, 119 of them were examined and X-rayed as was another group of 40 patients in 1980. The results of those examined could be compared with a group of patients treated without 224Ra. Patients with 224Ra demonstrated a long-lasting period of subjective improvement after the treatment, with reduced consumption of antirheumatoid and analgesic drugs, on the average. Blood examinations show inflammatory activities. Nevertheless, the ankylosing spondylitis proceeded. In the final stages of the disease, neither the clinical aspects nor the X-rays showed any specific effect due to 224Ra. Blood examinations, especially blood cells and liver, had shown no specific changes. We observed no case of malignant bone tumor. Of the 169 examined patients, 22 had a total of 32 children after the treatment with 224Ra. Among these was a set of twins with cerebral palsy and diabetes insipidus renalis. In conclusion, 224Ra in ankylosing spondylitis is a recommended treatment without higher risk compared to the common therapy with drugs.
1952年至1980年间，法兰克福大学骨科医院用镭-224对约250例强直性脊柱炎患者进行了治疗。1970年，对其中119例患者进行了检查并拍摄了X光片，1980年又对另外40例患者进行了同样的检查。这些接受检查的患者的结果可以与一组未接受镭-224治疗的患者进行比较。接受镭-224治疗的患者在治疗后出现了长期的主观改善，平均而言，抗风湿和止痛药物的消耗量有所减少。血液检查显示有炎症活动。然而，强直性脊柱炎仍在发展。在疾病的最后阶段，无论是临床症状还是X光片都未显示出镭-224有任何特殊效果。血液检查，特别是血细胞和肝脏检查，未显示出任何特殊变化。我们未观察到恶性骨肿瘤病例。在169例接受检查的患者中，有22例在接受镭-224治疗后共生育了32个孩子。其中有一对双胞胎患有脑瘫和肾性尿崩症。总之，与常用的药物治疗相比，镭-224治疗强直性脊柱炎是一种推荐的治疗方法，且风险不高。
