Cohen L, Creditor M
Int J Radiat Oncol Biol Phys. 1983 Jul;9(7):1065-71. doi: 10.1016/0360-3016(83)90398-x.
Available literature on radiation injury to normal tissue stroma and ablation of epidermoid carcinoma was surveyed. Computer programs (RAD3 and RAD1) were then used to derive cell kinetic parameters and generate iso-effect tables for the relevant tissues. The two tables provide a set of limiting doses for tolerance of normal connective tissue (16% risk of injury) and for ablation of epidermoid cancer (16% risk of recurrence) covering a wide range of treatment schedules. Calculating the ratios of normal tissue tolerance to tumor control doses for each treatment scheme provides an array of therapeutic ratios, from which appropriate treatment schemes can be selected.
我们查阅了有关正常组织基质辐射损伤和表皮样癌消融的现有文献。然后使用计算机程序（RAD3和RAD1）推导细胞动力学参数，并为相关组织生成等效应表。这两个表提供了一组正常结缔组织耐受性（损伤风险16%）和表皮样癌消融（复发风险16%）的极限剂量，涵盖了广泛的治疗方案。计算每种治疗方案的正常组织耐受性与肿瘤控制剂量的比值，可得到一系列治疗比，从中可以选择合适的治疗方案。
