Lilburn J K, Moore J, Dundee J W
Anaesthesia. 1978 Jun;33(6):499-505. doi: 10.1111/j.1365-2044.1978.tb08385.x.
In an attempt to attenuate the cardiostimulatory effects of ketamine, a number of drugs were given individually, or in combination, to fit adults undergoing body surface operations, either before or aftera ketamine induction of 1 mg kg-1 followed by an infusion of 1 mg ml-1. Of these, practolol, phentolamine, practolol-phentolamine, phentolamine-practolol, promethazine, hexamethonium, procainamide and verapamil were unacceptable. Labetalol, in doses of 0.5 mg kg-1 and 1.0 mg kg-1, proved to be the most promising drug and is worthy of further study.
为了减弱氯胺酮的心脏刺激作用，对一些接受体表手术的成年患者，在给予1mg/kg氯胺酮诱导剂量后，接着以1mg/ml的速度输注，在此之前或之后，单独或联合给予了多种药物。其中，心得宁、酚妥拉明、心得宁-酚妥拉明、酚妥拉明-心得宁、异丙嗪、六甲溴铵、普鲁卡因胺和维拉帕米均不可接受。拉贝洛尔，剂量为0.5mg/kg和1.0mg/kg，被证明是最有前景的药物，值得进一步研究。
