普萘洛尔治疗甲状腺毒症。术前用普萘洛尔治疗的患者在甲状腺切除术中的心血管变化。

Propranolol in thyrotoxicosis. Cardiovascular changes during thyroidectomy in patients pre-treated with propranolol.

作者信息

Trench A J, Buckley F P, Drummond G B, Arthur G R, Scott D B

出版信息

Anaesthesia. 1978 Jun;33(6):535-9. doi: 10.1111/j.1365-2044.1978.tb08392.x.

DOI:10.1111/j.1365-2044.1978.tb08392.x

Abstract

The cardiovascular changes during anaesthesia and thyroidectomy have been studied in seven thyrotoxic patients prepared with propranolol. The heart rate and cardiac rhythm remained very stable throughout surgery. A 20% increase in mean arterial pressure occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgical stimulation. A decrease in cardiac output, due to decreased stroke volume, occurred during surgery, reaching a maximum of 21% during ligation of the thyroid vessels and returning to pre-operative values by the end of surgery. The fall in cardiac output was accompanied by raised central venous pressure and raised total peripheral resistance.

摘要

对七名用普萘洛尔做术前准备的甲状腺毒症患者在麻醉和甲状腺切除术中的心血管变化进行了研究。在整个手术过程中，心率和心律保持非常稳定。手术刺激期间平均动脉压升高了20%。手术刺激期间，由于每搏量减少，心输出量降低。手术期间心输出量降低，在结扎甲状腺血管时降至最大降幅21%，手术结束时恢复到术前值。心输出量下降伴随着中心静脉压升高和总外周阻力升高。