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Chronic alcohol excess is associated with selective but reversible injury to type 2B muscle fibres.长期过量饮酒与2B型肌纤维的选择性但可逆性损伤有关。
J Clin Pathol. 1983 Jul;36(7):772-7. doi: 10.1136/jcp.36.7.772.
2
Fibre type changes in striated muscle of alcoholics.酗酒者横纹肌的纤维类型变化
J Clin Pathol. 1981 Sep;34(9):991-5. doi: 10.1136/jcp.34.9.991.
3
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4
Investigation of the organelle pathology of skeletal muscle in chronic alcoholism.慢性酒精中毒骨骼肌细胞器病理学研究
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5
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Alcohol Alcohol. 1989;24(6):533-9. doi: 10.1093/oxfordjournals.alcalc.a044956.
6
Chronic alcoholic skeletal myopathy--common and reversible.慢性酒精性骨骼肌病——常见且可逆。
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7
Fibre size, atrophy, and hypertrophy factors in vastus lateralis muscle from 18- to 29-year-old men.
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9
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2
Association Between Alcohol Consumption and Nocturnal Leg Cramps in Patients Over 60 Years Old: A Case-Control Study.酒精摄入与 60 岁以上患者夜间腿部痉挛的关联：病例对照研究。
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4
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5
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6
Selective damage to type 2B muscle fibres in ethanol-fed rats.乙醇喂养大鼠中2B型肌纤维的选择性损伤。
J Clin Pathol. 1983 Dec;36(12):1415-6. doi: 10.1136/jcp.36.12.1415-b.
7
Alcoholic myopathy.酒精性肌病
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8
Differential effects of ethanol on membrane-bound and soluble acetylcholinesterase from sarcoplasmic reticulum membranes.乙醇对肌浆网膜结合型和可溶性乙酰胆碱酯酶的不同作用
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MUSCULAR AFFECTIONS IN CHRONIC ALCOHOLISM.慢性酒精中毒中的肌肉病变
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Acute myoglobinuria; report of a case with fatal outcome.急性肌红蛋白尿；一例致死病例报告。
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Investigation of tissue organelles by a combination of analytical subcellular fractionation and enzymic microanalysis: a new approach to pathology.通过亚细胞分级分离分析与酶微分析相结合的方法对组织细胞器进行研究：病理学的一种新方法。
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5
Fibre type changes in striated muscle of alcoholics.酗酒者横纹肌的纤维类型变化
J Clin Pathol. 1981 Sep;34(9):991-5. doi: 10.1136/jcp.34.9.991.
6
Measurement of striated muscle fibre diameters using interactive computer-aided microscopy.使用交互式计算机辅助显微镜测量横纹肌纤维直径。
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Ethanol metabolism.乙醇代谢
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A spectrum of myopathy associated with alcoholism. II. Light and electron microscopic observations.
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Alcoholic myopathy.
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Alcoholic myopathy, a critical review.酒精性肌病：一篇综述
Ala J Med Sci. 1972 Jan;9(1):79-95.

长期过量饮酒与2B型肌纤维的选择性但可逆性损伤有关。

Chronic alcohol excess is associated with selective but reversible injury to type 2B muscle fibres.

作者信息

Slavin G, Martin F, Ward P, Levi J, Peters T

出版信息

J Clin Pathol. 1983 Jul;36(7):772-7. doi: 10.1136/jcp.36.7.772.

DOI:10.1136/jcp.36.7.772
PMID:6863569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC498386/
Abstract

Patients drinking more than 100 g alcohol/day for longer than three years develop atrophy of striated muscle fibres. This predominantly affects type 2B fibres which are dependent on anaerobic glycolytic metabolism. Atrophy of type 1 and type 2A fibres, which in addition use aerobic mitochondrial respiration, only occurs in the most severe cases and then only to a lesser degree. Abstention from alcohol reverses the changes in muscle which slowly return to normal. Selective injury to type 2B fibres indicates that search should be made for an alcohol-induced biochemical lesion affecting the anaerobic glycolytic pathways of the muscle fibre.

摘要

每天饮酒超过100克且持续三年以上的患者会出现横纹肌纤维萎缩。这主要影响依赖无氧糖酵解代谢的2B型纤维。1型和2A型纤维除了利用有氧线粒体呼吸外，其萎缩仅在最严重的情况下发生，且程度较轻。戒酒可逆转肌肉变化，肌肉会缓慢恢复正常。对2B型纤维的选择性损伤表明，应该寻找一种酒精诱导的影响肌纤维无氧糖酵解途径的生化损伤。