长期过量饮酒与2B型肌纤维的选择性但可逆性损伤有关。
Chronic alcohol excess is associated with selective but reversible injury to type 2B muscle fibres.
作者信息
Slavin G, Martin F, Ward P, Levi J, Peters T
出版信息
J Clin Pathol. 1983 Jul;36(7):772-7. doi: 10.1136/jcp.36.7.772.
Abstract
Patients drinking more than 100 g alcohol/day for longer than three years develop atrophy of striated muscle fibres. This predominantly affects type 2B fibres which are dependent on anaerobic glycolytic metabolism. Atrophy of type 1 and type 2A fibres, which in addition use aerobic mitochondrial respiration, only occurs in the most severe cases and then only to a lesser degree. Abstention from alcohol reverses the changes in muscle which slowly return to normal. Selective injury to type 2B fibres indicates that search should be made for an alcohol-induced biochemical lesion affecting the anaerobic glycolytic pathways of the muscle fibre.
摘要
每天饮酒超过100克且持续三年以上的患者会出现横纹肌纤维萎缩。这主要影响依赖无氧糖酵解代谢的2B型纤维。1型和2A型纤维除了利用有氧线粒体呼吸外，其萎缩仅在最严重的情况下发生，且程度较轻。戒酒可逆转肌肉变化，肌肉会缓慢恢复正常。对2B型纤维的选择性损伤表明，应该寻找一种酒精诱导的影响肌纤维无氧糖酵解途径的生化损伤。
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