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甲状腺切除猪对推注钙注射的瞬时反应以及鲑鱼降钙素和甲状旁腺激素的作用。

Transient response of thyroidectomized pigs to bolus calcium injections and the effect of salmon calcitonin and parathyroid hormone.

作者信息

Jaros G G, Van Hoorn-Hickman R, Maier H, Newman E

出版信息

J Endocrinol Invest. 1983 Apr;6(2):95-100. doi: 10.1007/BF03350579.

DOI:10.1007/BF03350579
PMID:6863850
Abstract

The intravenous injection of calcium gluconate (0.11 mM/kg body weight) into conscious thyroidectomized pigs elicits a 30% rise in both ionized and total calcium concentrations of plasma, which return to basal levels within 180 min. The administration of calcitonin (2.5-10 MRC U/kg body weight) reduces this time to 30 to 40 min which is similar to the time obtained in thyroid intact animals. These results suggest that calcitonin may be involved in the fast calcium removal processes and thus in the short-term regulating system of calcium homeostasis. Neither parathyroidectomy nor the administration of parathyroid hormone affected the time for recovery in thyroidectomized pigs, suggesting that the short-term regulation is independent on the parathyroid gland and its hormone.

摘要

向清醒的甲状腺切除猪静脉注射葡萄糖酸钙(0.11 mM/kg体重)会使血浆中离子钙和总钙浓度升高30%,并在180分钟内恢复到基础水平。注射降钙素(2.5 - 10 MRC U/kg体重)可将恢复时间缩短至30至40分钟,这与甲状腺完整动物的情况相似。这些结果表明,降钙素可能参与了快速的钙清除过程,从而参与了钙稳态的短期调节系统。甲状旁腺切除术或注射甲状旁腺激素均未影响甲状腺切除猪的恢复时间,这表明短期调节独立于甲状旁腺及其激素。

相似文献

1
Transient response of thyroidectomized pigs to bolus calcium injections and the effect of salmon calcitonin and parathyroid hormone.甲状腺切除猪对推注钙注射的瞬时反应以及鲑鱼降钙素和甲状旁腺激素的作用。
J Endocrinol Invest. 1983 Apr;6(2):95-100. doi: 10.1007/BF03350579.
2
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Transient response of the calcium homeostatic system of the conscious pig to bolus calcium injections.清醒猪钙稳态系统对推注钙注射的瞬态反应。
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本文引用的文献

1
EVIDENCE FOR THE EXISTENCE OF THYROCALCITONIN IN THE RAT.大鼠体内存在甲状腺降钙素的证据。
Endocrinology. 1965 Jan;76:103-7. doi: 10.1210/endo-76-1-103.
2
THYROID HYPOCALCEMIC PRINCIPLE AND RECURRENT LARYNGEAL NERVE INJURY AS FACTORS AFFECTING THE RESPONSE TO PARATHYROIDECTOMY IN RATS.甲状腺低钙血症原理及喉返神经损伤作为影响大鼠甲状旁腺切除反应的因素
Endocrinology. 1963 Aug;73:244-52. doi: 10.1210/endo-73-2-244.
3
Evidence for calcitonin--a new hormone from the parathyroid that lowers blood calcium.降钙素的证据——一种来自甲状旁腺的新激素,可降低血钙水平。
Endocrinology. 1962 May;70:638-49. doi: 10.1210/endo-70-5-638.
4
Relationship between plasma calcium concentration and calcitonin secretion in piglings.仔猪血浆钙浓度与降钙素分泌之间的关系。
Natl Inst Anim Health Q (Tokyo). 1980 Spring;20(1):36-7.
5
Effect of calcitonin and glutocorticoids in combination on the hypercalcemia of malignancy.降钙素与糖皮质激素联合应用对恶性肿瘤高钙血症的影响。
Ann Intern Med. 1980 Aug;93(2):269-72. doi: 10.7326/0003-4819-93-2-269.
6
Calcitonin secretion in congenital nongoitrous cretinism.先天性非甲状腺肿型克汀病中的降钙素分泌
J Clin Invest. 1980 Apr;65(4):892-5. doi: 10.1172/JCI109742.
7
Transient response of the calcium homeostatic system of the conscious pig to bolus calcium injections.清醒猪钙稳态系统对推注钙注射的瞬态反应。
Am J Physiol. 1982 Jul;243(1):R125-30. doi: 10.1152/ajpregu.1982.243.1.R125.
8
Evidence for an important physiological role for calcitonin.降钙素具有重要生理作用的证据。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):609-13. doi: 10.1073/pnas.77.1.609.
9
Thyrocalcitonin: inhibitor of bone resorption in tissue culture.甲状腺降钙素:组织培养中骨吸收的抑制剂。
Science. 1965 Dec 10;150(3702):1465-7. doi: 10.1126/science.150.3702.1465.
10
Thyrocalcitonin.甲状腺降钙素
Surg Forum. 1965;16:55-7.