Carey D E, Jones K L, Parthemore J G, Deftos L J
J Clin Invest. 1980 Apr;65(4):892-5. doi: 10.1172/JCI109742.
Plasma calcitonin (CT) was measured in the basal state and/or during provocative tests of hormone secretion in 11 children with congenital non-goitrous cretinism (CNC), in 1 girl with a lingual thyroid, and in 11 normal children. Basal and stimulated CT concentrations were significantly lower in the patients with CNC than in the normal subjects. Mean basal CT (+/- SE) was 41 +/- 4 pg/ml in the normal children, 24 +/- 3 pg/ml in the children with CNC, and 20 +/- 2 pg/ml in the patient with the lingual thyroid. The mean incremental CT responses to calcium infusion were 7.0 +/- 2 pg/ml in the children with CNC, 6.0 pg/ml in the patient with the lingual thyroid, and 146 +/- 47 pg/ml in the normal children. The children with CNC also demonstrated a significant delay in the return of the total serum calcium to basal level after the calcium infusion. The mean incremental CT response after infusion of pentagastrin was 7.6 +/- 2 pg/ml in the children with CNC, 10.0 pg/ml in the child with the lingual thyroid, and 34.4 +/- 11 pg/ml in the normal children. These data indicate that CT deficiency is present in children with CNC and suggest that the deficiency is a consequence of the defective embryologic development of the thyroid gland.
对11名先天性非甲状腺肿型克汀病（CNC）患儿、1名患有舌甲状腺的女孩以及11名正常儿童，在基础状态下和/或激素分泌激发试验期间测定了血浆降钙素（CT）。CNC患儿的基础和刺激后的CT浓度显著低于正常受试者。正常儿童的平均基础CT（±标准误）为41±4 pg/ml，CNC患儿为24±3 pg/ml，舌甲状腺患者为20±2 pg/ml。CNC患儿对钙输注的平均CT增量反应为7.0±2 pg/ml，舌甲状腺患者为6.0 pg/ml，正常儿童为146±47 pg/ml。CNC患儿在钙输注后血清总钙恢复到基础水平也有显著延迟。CNC患儿输注五肽胃泌素后的平均CT增量反应为7.6±2 pg/ml，舌甲状腺患儿为10.0 pg/ml，正常儿童为34.4±11 pg/ml。这些数据表明CNC患儿存在CT缺乏，并提示这种缺乏是甲状腺胚胎发育缺陷的结果。
