Boer G J, Kruisbrink J, van Pelt-Heerschap H
J Endocrinol. 1983 Jul;98(1):147-52. doi: 10.1677/joe.0.0980147.
A long-lasting and constant release of vasopressin in serum solution (in vitro) for periods up to 50 days can be obtained by the use of small-diameter microporous Accurel polypropylene tubing, filled with vasopressin and covered with collodion. The potency of the preparation is shown in vivo after subcutaneous implantation in the adult vasopressin-deficient Brattleboro rat, for which normal levels of urine production and osmolality were achieved at least for 1 month. The possible use of this method for other peptides and its application in small or immature laboratory animals and in fetuses is emphasized.
通过使用填充有加压素并覆盖有火棉胶的小直径微孔Accurel聚丙烯管，可在血清溶液（体外）中实现长达50天的加压素长效持续释放。将该制剂皮下植入成年加压素缺乏的Brattleboro大鼠体内后，其效力得以体现，至少1个月内可使大鼠的尿量和渗透压维持在正常水平。文中强调了该方法用于其他肽类的可能性及其在小型或未成熟实验动物和胎儿中的应用。
