Cardosa M J, Porterfield J S, Gordon S
J Exp Med. 1983 Jul 1;158(1):258-63. doi: 10.1084/jem.158.1.258.
Evidence is presented that M phi complement receptors (CR3) mediate IgM-dependent enhancement of flavivirus replication in the presence of complement. Enhancement is blocked by pretreatment of macrophages with monoclonal antibody Ml/70, which inhibits CR3 binding, but not by pretreatment with monoclonal antibody 2.4G2, which inhibits FcR binding.
有证据表明,在补体存在的情况下,巨噬细胞补体受体(CR3)介导黄病毒复制的IgM依赖性增强。用抑制CR3结合的单克隆抗体Ml/70预处理巨噬细胞可阻断这种增强作用,但用抑制FcR结合的单克隆抗体2.4G2预处理则不能阻断。